July 20, 2025

How PLLACUBE Delivers Results with MTS, Laser & Topical Use

Q: 1. What is PLLACUBE Original?

PLLACUBE Original is a 5th-generation Korean skinbooster containing Poly-L-Lactic Acid (PLLA), PDRN, Vitamin C, Glutathione, Hyaluronic Acid, and Houttuynia Cordata extract. It is designed for topical use with microneedling to support skin rejuvenation, firmness, and radiance.

Q: 2. What makes PLLACUBE different from other skinboosters?

PLLACUBE is a multi-functional skinbooster that uniquely combines PLLA, PDRN, Glutathione, Vitamin C, Hyaluronic Acid, and plant-derived exosomes into a single freeze-dried formula. It features InCube™ Technology, which helps protect fragile actives from oxidation and degradation — ensuring maximum potency upon reconstitution.

Q: 3. How is PLLACUBE used in clinical settings?

PLLACUBE is designed for professional use across a range of advanced skin rejuvenation protocols, including microneedling, RF microneedling, infusion-focused treatments like JetPeel™ or CureJet™, and post-laser care such as CO₂ fractional or thulium laser procedures. Once reconstituted, the solution may be applied topically or paired with appropriate delivery systems to optimize absorption. Usage volume and dilution may vary based on clinical technique and goals.

Q: 4. Who is PLLACUBE suitable for?

PLLACUBE is intended for professional topical application in clinical or medical aesthetic settings. It is suitable for clients seeking: • Skin hydration and radiance • Improved elasticity and firmness • Refined pore appearance • Post-laser recovery support While results may vary, PLLACUBE is ideal for individuals undergoing cosmetic procedures like microneedling, RF-based therapies, or non-ablative laser treatments. For professional use only. Not intended for self-application.

Q: 5. What is INCUBE™ Technology?

INCUBE™ is a patented technology (Patent No. 10-2488551) that protects active ingredients from degradation through selective encapsulation and timed release, enhancing overall efficacy and stability of the formula.This platform minimizes oxidation and degradation, allowing actives like Vitamin C and Glutathione to remain stable until reconstitution. InCube™ ensures enhanced ingredient performance during topical application.

Q: 6. Why is PLLACUBE used as an injection in some countries?

PLLACUBE was originally developed as a topical-use cosmetic skinbooster, specifically designed to pair with microneedling treatments. It is manufactured as an injection-grade sterile product to meet the highest safety standards. In some countries, PLLACUBE is registered as a medical device, which allows its use via injection. However, in the North American market (Canada and the U.S.), PLLACUBE is officially classified and registered as a cosmetic product for topical application only. it is intended strictly for topical professional use, often in conjunction with microneedling, RF microneedling, Infusion-focused medi-facials (e.g. JetPeel, Curejet, etc.), or post-laser-procedures.

Q: 7. Is PLLACUBE Health Canada approved?

Yes. PLLACUBE is registered with Health Canada as a cosmetic product for topical use

Q: 8. Can PLLACUBE be combined with other skinbooster?

It is best applied as a standalone booster step due to its multi-ingredient formula.

Q: 9. Does PLLACUBE require refrigeration or special storage?

No refrigeration is needed. PLLACUBE is freeze-dried for stability and should be stored in a cool, dry place away from direct sunlight. Reconstitute with distilled water or saline only when ready to use.

Q: 10. Is PLLACUBE safe for all skin types?

PLLACUBE is dermatologist-tested and shown to be non-irritating in clinical trials. It is suitable for most skin types, including normal to mildly sensitive skin. As with all professional-use products, a clinical evaluation is recommended before use

by Derma Essence Team in Insights

PLLACUBE's Versatility: One Formula, Many Applications

Professional skin rejuvenation — tailored to your method.

Not all skinboosters are created equal. PLLACUBE stands apart not only because of its innovative InCube™ stabilization technology, but also for how versatile it is across different treatment modalities. From microneedling to CO₂ laser to topical aftercare — PLLACUBE adapts to your clinical workflow.

Real-World Application Methods in Korea

Used by professionals in combination with:

Microneedling (MTS)

PLLACUBE Microneedling

CO₂ Fractional Laser

PLLACUBE CO2 Laser 1
PLLACUBE CO2 Laser 2

Lutronic LaseMD Ultra

PLLACUBE LaseMD 1
PLLACUBE LaseMD 2

Needle-Free Injector (CureJet)

PLLACUBE CureJet

Clinically Measured Benefits in 3 Weeks

GCP-certified clinical study (Human Co. Ltd., 2024) demonstrated statistically significant improvements in:

Epidermal & deep elasticity
Surface & deep moisture levels
Skin tone brightness
Texture refinement
Pore volume reduction

✅ 30 healthy participants (ages 26–69) used PLLACUBE over 3 weeks under a controlled protocol involving MTS and booster application.

Safety Verified — 0.00 Skin Irritation Index

Rated ‘Excellent’ for even the most sensitive skin after a 24-hour occlusive patch test on 33 adults with clinically confirmed sensitive skin.

Conducted under GCP guidelines and MFDS-approved methodology
Evaluated by dermatologists at Human Co., Ltd. Skin Clinical Trial Center
Compliant with international safety testing standards

Moisture Boost: Before & After Clinical Images

Device: Epsilon E100 (Biox Systems, UK)
Brighter areas = higher epidermal moisture
Measured at 22°C / 50% RH (GCP-compliant setting)

+48.95% increase in average dielectric constant (ε)
100% of participants reported perceived moisture improvement

PLLACUBE Moisture Clinical Result

Why Professionals Choose PLLACUBE

Freeze-dried capsule for freshness
Cyclodextrin complex protects Glutathione & Vitamin C
Tested under ISO standards for safety & sterility
Flexible pairing with MTS, RF, laser, JetPeel, and more
No parabens or artificial dyes — clean, professional formula

Ready to bring PLLACUBE into your clinic?
Learn more – Official Canadian Distributor: Derma Essence

*For professional topical cosmetic use only. This content summarizes cosmetic product testing and does not claim to diagnose, treat, or cure medical conditions.*

August 13, 2025

PLLACUBE: 0.00 Irritation Index & Clinically Proven Skin Improvements in 3 Weeks

0.00 Irritation Index — Rated ‘Excellent’ Dermatologist-evaluated 24-hour primary irritation test on clinically confirmed sensitive skin. Test Item Inspection Standard Result Irritation Evaluation Suitability test for sensitive skin (primary irritation) GCP & MFDS-approved protocol 0.00 No irritation (Excellent) Test Method: Test site wiped with 70% ethanol, product loaded in a Finn Chamber® and attached for 24 hours. Irritation assessed at 30 min & 24 hrs post-removal.Test Location: Human Co., Ltd. Skin Clinical Trial Center, Korea.Participants: 33 adults with clinically confirmed sensitive skin. Clinically Measured Results at 3 Weeks Single-arm evaluation (n=30). All changes significant vs. baseline (p<0.001). Deep Hydration (TDC) +14.19% Moisturemeter D Skin Brightness (L*) +0.78% Mark-Vu Colorimeter Skin Texture (Ra, μm) −7.58% Antera 3D Dermis (Deep) Elasticity +2.46% Cutometer R2 • 8 mm Epidermal Elasticity +3.82% Cutometer R2 • 2 mm Skin Pores (Volume) −13.04% Antera 3D Methods: Moisturemeter D (TDC); Mark-Vu Colorimeter (L*); Antera 3D (Ra, mean pore volume); Cutometer dual MPA 580 R2 (2 mm & 8 mm). Human Co., Ltd. Skin Clinical Trial Center, Korea. Three-week application; results mean ± SD; all p<0.001 vs. baseline.

Learn more

March 27, 2025

What Is PLLACUBE? Meet the Science-Driven Cosmetic Skin Booster for Professional Use

Introduction – What Is PLLACUBE? PLLACUBE is an advanced all-in-one cosmetic skin booster developed for professional use in medspas, aesthetic clinics, and skin care studios. It features a science-backed formulation designed to support hydration, radiance, and skin conditioning — all while leveraging the patented INCUBE™ technology developed by Labincube Co., Ltd. in South Korea. Backed by Material Science: The INCUBE™ Innovation Founded in 2021, Labincube specializes in porous carrier materials and has developed a proprietary technology called INCUBE™ — based on Metal-Organic Frameworks (MOFs). This material helps stabilize active cosmetic ingredients and supports consistent formulation performance by controlling the release and integrity of ingredients such as Vitamin C and Glutathione. In other words, INCUBE™ acts as a delivery-support material that ensures cosmetic actives remain well-dispersed and stable until applied. PLLACUBE Skin Booster – Cosmetic Actives, Balanced Formulation There are two topical cosmetic products in the PLLACUBE lineup: PLLACUBE Original Poly-L-Lactic Acid (PLLA): Supports the appearance of skin elasticity and firmness PDRN (Sodium DNA): Conditions and hydrates skin for a revitalized appearance Vitamin C (Ethyl Ascorbyl Ether): Offers antioxidant support for a radiant-looking complexion Glutathione: Enhances skin brightness and overall glow Sodium Hyaluronate (HA): Helps maintain skin moisture Houttuynia Cordata Extract (Plant-based Exosome): Known for calming and conditioning effects PLLACUBE PiNk VoL. PLLA, PN (Polydeoxyribonucleotide), Vitamin C, Glutathione, and HA for similar cosmetic skin conditioning effects PLLACUBE Cosmetic Use & Professional Application Intended for professional use in cosmetic skin treatments Global Expansion & Industry Recognition PLLACUBE has been showcased at major industry events including: Cosmoprof Bologna (Italy) KIMES Seoul (International Medical Equipment Exhibition) These events spotlight innovation in cosmetic technology and skincare — and PLLACUBE has attracted attention for its ingredient integrity and cosmetic formulation science. Now Available in Canada Derma Essence Canada Ltd. is the official distributor of PLLACUBE products across Canada and North America. We are committed to providing professional-use, compliant cosmetic solutions backed by science, formulation stability, and visual performance. Interested in Offering PLLACUBE at Your Clinic? Contact us at info@derma-essence.com or explore our professional-use collection at www.derma-essence.com

Learn more

How PLLACUBE Delivers Results with MTS, Laser & Topical Use